⏰ Intermittent Fasting Guide — 16/8, 5:2 & Time-Restricted Eating⏰ 间歇性断食完全指南 — 168断食法、5:2断食法与限时进食

📑 Table of Contents📑 目录

⏳ What Is Intermittent Fasting?⏳ 什么是间歇性断食?

Intermittent fasting (IF) is an eating pattern that alternates between periods of eating and fasting. Unlike traditional diets that tell you what to eat, IF focuses on when you eat. It is not a diet in the conventional sense — it is an eating schedule.间歇性断食(IF)是一种在进食和禁食之间交替的饮食模式。与传统饮食告诉你 吃什么 不同,IF 关注的是 什么时候吃。从严格意义上讲它不是一个"节食方案",而是一种进食时间表。

The concept is simple: you restrict your daily eating to a specific window of time, and fast for the remaining hours. During the fasting period, you consume no calories — water, black coffee, and unsweetened tea are generally allowed.原理很简单:你把一天当中吃东西的时间限制在某个特定的时间段内,其余时间禁食。在禁食期间不摄入任何热量——可以喝水、黑咖啡和无糖茶。

"Intermittent fasting is not about starving yourself — it is about giving your body a sustained break from digestion so it can focus on repair and fat burning." "间歇性断食不是让你挨饿——而是给消化系统一个持续休息的机会,让身体专注于修复和燃脂。"

Intermittent fasting has gained immense popularity in recent years, backed by a growing body of research showing benefits for weight loss, metabolic health, cellular repair (autophagy), and even longevity. It is also one of the simplest health interventions to implement because it does not require expensive supplements, complex meal prep, or drastic changes to what you eat.近年来,间歇性断食备受追捧,大量研究也证实了它在 减肥、改善代谢健康、促进细胞自噬、甚至延长寿命 等方面的益处。它也是最好实施的健康干预手段之一——不需要昂贵的补剂、复杂的备餐、或者大幅改变你的饮食内容。

Popular IF Methods常见的断食方法

There are several ways to practice intermittent fasting. The most common methods differ in fasting duration and weekly frequency. Here is a comparison of the major approaches:间歇性断食有多种方式。最常见的几种方法在禁食时长和每周频率上有所不同。以下是主要方法的对比:

Method方法 Fasting Duration禁食时长 Eating Window进食窗口 Frequency频率 Difficulty难度
16:8 (Leangains)16:8(Leangains 法) 16 hours16 小时 8 hours (e.g. 12:00–20:00)8 小时(例如 12:00~20:00) Daily每天 Easy容易
5:2 Diet5:2 断食法 24 hours (×2/week)24 小时(每周 2 次) ~500 kcal on fast days断食日约 500 大卡 2 fast days / week每周 2 天 Moderate中等
OMAD (23:1)OMAD(23:1) 23 hours23 小时 1 hour (one meal)1 小时(一顿饭) Daily每天 Hard困难
Alternate-Day Fasting (ADF)隔日断食(ADF) 36 hours36 小时 12 hours every other day每隔一天吃 12 小时 Every other day隔天 Very Hard很难
Warrior Diet (20:4)战士饮食(20:4) 20 hours20 小时 4 hours (one large meal + snacks)4 小时(一大餐 + 小食) Daily每天 Hard困难
🌟 Best for beginners:🌟 最适合新手: Start with the 16:8 method. It is the most sustainable and easiest to incorporate into daily life — simply skip breakfast and eat your first meal around noon. 16:8 断食法 开始。它最容易坚持且融入日常生活——简单跳过早餐,中午再吃第一顿即可。

🧬 Health Benefits of Intermittent Fasting🧬 断食的健康益处

When you fast, several important biological processes occur in your body. The benefits go far beyond simple calorie restriction:当你禁食时,身体内会发生多个重要的生物过程。其益处远不止简单的热量限制:

🔥 Weight Loss & Fat Burning🔥 减肥与燃脂

The most obvious benefit. IF naturally reduces calorie intake by limiting the hours available for eating. Additionally, during fasting, insulin levels drop significantly, which signals your body to start burning stored fat for energy. Studies show that IF can lead to 3~8% weight loss over 3~24 weeks — comparable to traditional calorie-restricted diets, but often easier to adhere to.这是最明显的益处。IF 通过限制进食时间自然减少了热量摄入。此外,在禁食期间胰岛素水平大幅下降,向身体发出开始燃烧储存脂肪供能的信号。研究表明,IF 可以在 3~24 周内使体重 减少 3~8%——效果与传统限制热量饮食相当,但通常更容易坚持。

🔄 Autophagy — Cellular Cleanup🔄 细胞自噬——身体的"大扫除"

Autophagy (literally "self-eating") is a natural cellular process where your body cleans out damaged cells and regenerates new ones. Fasting is one of the most potent triggers of autophagy. When cells are starved of nutrients, they recycle old, dysfunctional proteins and organelles to produce energy. This process is linked to anti-aging, immune function, and reduced inflammation.自噬(字面意思"自己吃自己")是一种天然的细胞过程,身体会清理受损细胞并再生新细胞。断食是触发自噬最有效的方法之一。当细胞缺乏营养时,会回收旧的和功能失调的蛋白质和细胞器来产生能量。这一过程与 抗衰老、免疫功能增强和减少炎症 相关。

The 2016 Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy — research that was partly conducted in yeast cells subjected to starvation. 2016 年诺贝尔生理学或医学奖授予大隅良典,以表彰他在自噬机制方面的发现——部分研究正是在遭受饥饿的酵母细胞中进行的。

⚡ Important nuance: While autophagy is well-documented in animal and cellular studies, the evidence for significant autophagy induction through typical 16/8 intermittent fasting in humans is less clear. Most animal studies showing robust autophagy used fasting periods of 24~48 hours or genetic models — much longer than the daily 16-hour fast of 16:8. The primary weight-loss mechanism of 16:8 remains calorie restriction (fewer eating hours → fewer calories). The metabolic benefits (improved insulin sensitivity, reduced inflammation) are real and well-supported, but attributing them primarily to autophagy overstates the current human evidence. ⚡ 重要说明:虽然自噬在 动物和细胞研究 中已被充分证实,但对于 人类采用常见的 16/8 断食法 是否能显著诱导自噬,证据尚不明确。大多数显示强烈自噬效应的动物研究使用了 24~48 小时禁食或基因改造模型——远长于 16:8 方案中每天 16 小时的禁食时长。16:8 断食法的主要减重机制仍然是 热量控制(进食时间缩短 → 摄入减少)。其代谢益处(改善胰岛素敏感性、减轻炎症)是真实且有充分证据支持的,但如果将其主要归因于自噬,则夸大了目前的人体研究证据。

💉 Improved Insulin Sensitivity💉 改善胰岛素敏感性

Intermittent fasting can significantly reduce fasting insulin levels and improve insulin sensitivity. Lower insulin means your body is better able to manage blood sugar, reducing the risk of type 2 diabetes. A 2018 review found that IF reduced fasting insulin by 20~31% and fasting blood glucose by 3~6% in overweight adults.间歇性断食可以显著降低空腹胰岛素水平并改善胰岛素敏感性。较低的胰岛素意味着身体能更好地管理血糖,降低 2 型糖尿病 风险。2018 年的一项综述发现,IF 可使超重成年人的空腹胰岛素降低 20~31%,空腹血糖降低 3~6%

🧠 Brain Health & Longevity🧠 大脑健康与长寿

Animal studies suggest that IF may promote brain health by increasing the production of brain-derived neurotrophic factor (BDNF), a protein that supports neuron survival and cognitive function. IF has also been shown to reduce oxidative stress and inflammation — two key drivers of aging. While human longevity data is still limited, the metabolic improvements are well-documented.动物研究表明,IF 可以通过增加脑源性神经营养因子(BDNF)的产生来促进大脑健康——这是一种支持神经元存活和认知功能的蛋白质。IF 还被证明可以减少氧化应激和炎症——两大衰老驱动因素。虽然人类长寿数据仍然有限,但其代谢改善方面的证据已经很充分。

  • Weight loss: 3~8% body weight reduction over 3~24 weeks减肥:3~24 周内减少 3~8% 体重
  • Fat loss: Up to 4~7% reduction in visceral fat减脂:内脏脂肪减少最高达 4~7%
  • Insulin reduction: Fasting insulin drops 20~31%胰岛素降低:空腹胰岛素下降 20~31%
  • Blood glucose: Fasting glucose reduced by 3~6%血糖降低:空腹血糖降低 3~6%
  • Inflammation: C-reactive protein (CRP) reduced by up to 30%抗炎:C 反应蛋白(CRP)降低最多 30%

🚀 How to Start Intermittent Fasting🚀 如何开始断食

Jumping straight into 16 hours of fasting can be challenging if your body is used to eating from morning until night. Here is a gradual approach that works for most people:如果你的身体习惯从早吃到晚,直接跳到 16 小时禁食可能很有挑战性。以下是一个适合大多数人的循序渐进方案:

📆 Week 1–2: Skip the Late-Night Snack📆 第 1~2 周:戒掉宵夜

Stop eating after 8 PM. This alone creates a 12-hour overnight fast (e.g., 20:00 to 08:00). This is also called 12:12 fasting and is already a huge improvement for digestive health.晚上 8 点后不再进食。仅此一项就可以创造 12 小时的夜间禁食(例如 20:00 到 08:00)。这也被称为 12:12 断食,对消化健康已经是巨大的改善。

📆 Week 3–4: Delay Breakfast📆 第 3~4 周:推迟早餐

Push your first meal to 10 AM, creating a 14:10 eating schedule. Drink water or black coffee in the morning if you need something.把第一餐推迟到上午 10 点,实现 14:10 的进食计划。如果早上需要一些东西,可以喝水或黑咖啡。

📆 Week 5+: 16:8📆 第 5 周之后:16:8

By week 5, aim for a 16:8 schedule — first meal at noon, last meal by 8 PM. This is where most people experience noticeable benefits. Stick with this for 1~2 months before trying more advanced methods.到第 5 周,目标是 16:8 计划——中午 12 点第一餐,晚上 8 点前最后一口。这是大多数人能感受到明显益处的阶段。坚持 1~2 个月后再尝试更高级的方法。

💡 Pro tip:💡 专业建议: Stay busy during your fasting window. Boredom is the #1 reason people break their fast early. Go for a walk, work on a project, or schedule your fasting hours during your busiest work period. 在禁食期间保持忙碌。无聊是人们提前打破禁食的头号原因。去散散步、专注于工作、或者把你的禁食时间安排在一天中最忙的时候。

📋 Sample 16:8 Daily Schedule📋 16:8 一日时间表示例

Time时间 Action行动 Notes备注
08:00 – 12:0008:00 – 12:00 Fasting禁食 Water, black coffee, or green tea only仅喝水、黑咖啡或绿茶
12:0012:00 Break fast (lunch)第一餐(午餐) Balanced meal: protein + vegetables + complex carbs均衡一餐:蛋白质 + 蔬菜 + 复合碳水
15:0015:00 Snack (optional)小吃(可选) Nuts, fruit, or yogurt坚果、水果或酸奶
19:00 – 20:0019:00 – 20:00 Dinner晚餐 Last meal before fasting window starts禁食窗口开始前的最后一餐
20:00 – 12:0020:00 – 12:00 Fasting (next day)禁食(次日) 16-hour overnight fast including sleep包含睡眠在内的 16 小时禁食

🥗 What to Eat & Drink During Intermittent Fasting🥗 断食期可以吃什么?

What you consume during your eating window matters. While IF gives flexibility on timing, the quality of your food still determines your results. Here is a quick reference:你在进食窗口期间吃什么很重要。虽然 IF 在时间上给了你灵活性,但食物的质量仍然决定了你的结果。以下是一个快速参考:

Category类别 Allowed ✅允许 ✅ Avoid ❌避免 ❌
Beverages (fasting)饮品(禁食期间) Water, sparkling water, black coffee, unsweetened green/black tea白水、气泡水、黑咖啡、无糖绿茶/红茶 Milk, cream, sugar, honey, soda, juice, sweetened drinks (all break a fast)牛奶、奶油、糖、蜂蜜、汽水、果汁、含糖饮料(均会打破禁食)
Proteins蛋白质 Lean meat, poultry, fish, eggs, tofu, legumes, Greek yogurt瘦肉、禽肉、鱼、蛋、豆腐、豆类、希腊酸奶 Processed meats high in sugar (e.g., honey-glazed ham, sausages with fillers)含糖高的加工肉类(如蜜汁火腿、含填充物的香肠)
Vegetables蔬菜 All vegetables — especially leafy greens, broccoli, bell peppers, tomatoes所有蔬菜——尤其深色绿叶菜、西兰花、彩椒、番茄 Vegetables cooked in heavy cream, butter, or sugary sauces用大量奶油、黄油或含糖酱汁烹制的蔬菜
Fruits水果 Berries, apples, citrus, melon (in moderation)莓果、苹果、柑橘、瓜类(适量) Dried fruit, fruit juice, large amounts of high-sugar fruit (grapes, mango)果干、果汁、大量高糖水果(葡萄、芒果)
Grains & Carbs谷物和碳水 Oats, quinoa, brown rice, whole-wheat bread, sweet potatoes燕麦、藜麦、糙米、全麦面包、红薯 Refined white bread, pastries, sugary cereals, white rice (large portions)精制白面包、糕点、含糖麦片、白米饭(过量)
Fats脂肪 Avocado, olive oil, nuts, seeds, fatty fish (salmon, mackerel)牛油果、橄榄油、坚果、种子、高脂鱼(三文鱼、鲭鱼) Trans fats, deep-fried foods, excessive processed oils反式脂肪、油炸食品、过量加工植物油

During your eating window, focus on whole, nutrient-dense foods. Aim for a balanced plate: lean protein + plenty of vegetables + healthy fats + complex carbohydrates. Avoid using your eating window as an excuse to binge on junk food — the health benefits of IF hinge on overall dietary quality.在你的进食窗口内,专注于 完整、营养密集的食物。追求均衡的一餐:瘦肉蛋白 + 大量蔬菜 + 健康脂肪 + 复合碳水。不要把你的进食窗口当作放纵垃圾食品的借口——IF 的健康益处最终取决于整体的饮食质量。

⚠️ Common Mistakes Beginners Make⚠️ 新手常见错误

Avoid these pitfalls to make your IF journey smoother and more effective:避免这些陷阱,让你的 IF 之旅更顺利、更有效:

  1. 🔴 Overeating in the eating window.🔴 进食窗口暴饮暴食。 "If I only have 8 hours to eat, I'd better eat double." — This defeats the purpose. IF works partly because of natural calorie reduction. Eat normally, not double. "既然只有 8 小时能吃东西,我得吃双份才行。"——这就失去了意义。IF 有效的原因之一就是自然减少了热量摄入。正常吃,不是吃双份。
  2. 🔴 Not drinking enough water.🔴 水喝得不够。 Hunger pangs are often thirst in disguise. During fasting, aim for 2~3 liters of water throughout the day. Add a pinch of salt for electrolytes if needed. 饥饿感往往是口渴的伪装。禁食期间一天要喝 2~3 升水。必要时加点盐补充电解质。
  3. 🔴 Breaking the fast with a huge, sugary meal.🔴 用一顿巨量含糖餐打破断食。 Your first meal after fasting should be balanced with protein, fiber, and healthy fats. A spike of sugar on an empty stomach can cause energy crashes and intense hunger. 断食后的第一餐应该均衡,包含蛋白质、纤维和健康脂肪。空腹吃糖会导致血糖剧烈波动和强烈的饥饿感。
  4. 🔴 Expecting immediate results.🔴 期望立即见效。 Your body needs 1~2 weeks to adapt to a new eating schedule. You might feel hungry, irritable, or tired at first. This is normal — it passes once your body becomes fat-adapted. 身体需要 1~2 周来适应新的进食时间表。一开始你可能会感到饥饿、烦躁或疲惫。这是正常的——一旦身体适应了以脂肪供能,这些感觉就会消失。
  5. 🔴 Ignoring nutrient quality.🔴 忽视营养质量。 IF is not a license to eat processed junk in your eating window. If you eat nutrient-poor food, you will feel terrible regardless of when you eat it. IF 不是你在进食窗口吃垃圾食品的许可证。如果你吃营养贫乏的食物,不管什么时候吃,感觉都不会好。
  6. 🔴 Fasting too aggressively too soon.🔴 一开始就断食过猛。 Do not jump straight into OMAD or 48-hour fasts. Start with 12:12, progress to 14:10, then 16:8. Let your body adapt gradually. 不要一上来就做 OMAD 或 48 小时断食。从 12:12 开始,到 14:10,再到 16:8。让身体逐渐适应。
💡 The 2-week rule:💡 两周规则: Give any IF method at least 2 weeks of consistent practice before deciding whether it works for you. The first few days are NOT representative of the long-term experience. 任何一种 IF 方法,至少坚持 2 周再决定它是否适合你。头几天的感受并不能代表长期体验。

🚫 Who Should NOT Practice Intermittent Fasting🚫 不适合断食的人群

Intermittent fasting is safe for most healthy adults, but it is not for everyone. The following groups should consult a doctor before starting — or avoid IF altogether:间歇性断食对大多数健康成年人来说是安全的,但并非人人适合。以下人群应咨询医生后再决定——或者完全避免断食:

  • Pregnant or breastfeeding women — increased nutritional needs make fasting unsafe for both mother and baby.孕妇或哺乳期女性——额外的营养需求使断食对母婴都不安全。
  • Children and adolescents — growing bodies require regular nourishment for development.儿童和青少年——生长发育需要规律的营养供应。
  • People with diabetes (especially type 1) — fasting can cause dangerous blood sugar fluctuations. Type 2 diabetics should only fast under medical supervision with adjusted medication.糖尿病患者(特别是 1 型)——禁食可能导致危险的血糖波动。2 型糖尿病患者也需在医生监督下调整药物后才能断食。
  • Individuals with a history of eating disorders — IF can trigger restrictive or binge behaviors in vulnerable individuals.有进食障碍史的人群——IF 可能诱发限制性进食或暴食行为。
  • Underweight individuals (BMI < 18.5) — fasting could lead to further unhealthy weight loss.体重过轻者(BMI < 18.5)——断食可能导致进一步的不健康体重下降。
  • People on certain medications — some medications need to be taken with food. Check with your doctor.正在服用特定药物的人群——有些药物需要随餐服用。请与医生确认。
  • Athletes in intense training — high-performance athletes may struggle to meet calorie and nutrient needs within a restricted eating window.高强度训练的运动员——高性能运动员在受限的进食窗口内可能难以满足热量和营养需求。
"If you have any underlying health condition or are unsure whether IF is right for you, talk to your doctor first. IF is a powerful tool — but like any tool, it must be used correctly and in the right context." "如果你有任何基础疾病或不确定 IF 是否适合你,请先咨询医生。IF 是一个强大的工具——但和其他工具一样,需要正确使用并在合适的情况下使用。"

❓ Frequently Asked Questions❓ 常见问题

Q: Can I drink coffee during my fasting window?Q:禁食期间可以喝咖啡吗?

A: Yes — black coffee (no sugar, milk, or cream) is fine. It contains virtually zero calories and may even enhance autophagy and fat burning. The same applies to unsweetened tea. Avoid bulletproof coffee (coffee with butter or MCT oil) during fasting — the fat calories will break your fast.A:可以——黑咖啡(不加糖、奶或奶油)没问题。它几乎不含热量,甚至可能增强自噬和燃脂效果。无糖茶也一样。禁食期间避免防弹咖啡(加黄油或 MCT 油的咖啡)——其中的脂肪热量会打破禁食。

Q: Will IF put me in "starvation mode" and slow my metabolism?Q:断食会让身体进入"饥饿模式"并降低代谢吗?

A: This is one of the most common myths. Short-term fasting (16~48 hours) does NOT cause "starvation mode." In fact, studies show that short-term fasting can increase metabolic rate by 3~14% due to the release of norepinephrine (adrenaline). True metabolic slowdown only occurs after prolonged calorie restriction (several days or weeks of severe undereating).A:这是最常见的误解之一。短期断食(16~48 小时)不会导致"饥饿模式"。事实上,研究表明短期断食可以通过释放去甲肾上腺素(肾上腺素)使代谢率 提高 3~14%。真正的代谢下降只有在长期热量限制(连续数天或数周严重进食不足)时才会发生。

Q: Can I work out while fasting?Q:可以在禁食期间运动吗?

A: Absolutely. In fact, many people find they perform better during fasted workouts because they are not digesting food. Fasted cardio is popular for fat burning. For heavy strength training, consider scheduling your workout near the end of your fasting window, so you can eat a protein-rich meal soon after. Listen to your body — if you feel dizzy or weak, break your fast.A:完全可以。事实上,很多人发现空腹运动时表现更好,因为不需要消化食物。空腹有氧对燃脂很有效。如果做力量训练,考虑把锻炼安排在禁食窗口结束前,这样之后可以马上吃一顿富含蛋白质的餐食。听从自己的身体——如果感到头晕或乏力,就结束禁食。

Q: Will I lose muscle on intermittent fasting?Q:间歇性断食会导致肌肉流失吗?

A: Studies suggest IF preserves muscle mass better than continuous calorie restriction, thanks to the boost in human growth hormone (HGH). One study found that 24-hour fasting increased HGH by as much as 2000% in men and 1300% in women. As long as you consume adequate protein (1.6~2.2 g/kg of body weight per day) during your eating window, muscle loss is not a concern.A:研究表明,由于人体生长激素(HGH)的提升,IF 比持续热量限制更能保护肌肉质量。一项研究发现,24 小时禁食可使 HGH 在男性中增加 2000%,在女性中增加 1300%。只要你在进食窗口内摄入足够的蛋白质(每日每公斤体重 1.6~2.2 克),就不必担心肌肉流失。

Q: Can women do intermittent fasting?Q:女性可以做间歇性断食吗?

A: Yes, but women may need a gentler approach. Some research suggests women's hormones are more sensitive to energy availability. A shorter fasting window (14:10 instead of 16:8) or a less aggressive schedule (like 5:2) may be better. Women should also watch their menstrual cycle — if your period becomes irregular, reduce or stop fasting. Always listen to your body and adjust accordingly.A:可以,但女性可能需要更温和的方法。一些研究表明女性激素对能量供应的变化更敏感。较短的禁食窗口(14:10 而不是 16:8)或强度较低的计划(如 5:2)可能更为合适。女性还需关注月经周期——如果月经不调,应减少或停止断食。始终听从身体的声音并做出相应调整。

Q: What should I eat to break my fast?Q:应该吃什么来开斋(结束禁食)?

A: Break your fast gently. A balanced meal with lean protein, vegetables, and some healthy fats and carbs is ideal. Avoid a massive sugar spike — a donut or sugary cereal on an empty stomach will send your blood sugar soaring and crashing. Good first-meal options: eggs with avocado and vegetables, a protein smoothie, Greek yogurt with berries, or a chicken salad with quinoa.A:温和地开斋。瘦肉蛋白、蔬菜、适量健康脂肪和碳水 的均衡餐是理想选择。避免血糖飙升——空腹吃甜甜圈或含糖麦片会导致血糖冲高又骤降。好的开斋餐选择:鸡蛋配牛油果和蔬菜、蛋白质奶昔、希腊酸奶配莓果、鸡肉藜麦沙拉。

The bottom line: Intermittent fasting is one of the most flexible and effective tools for weight management and metabolic health. Start with a gentle method like 16:8, stay hydrated, eat nutrient-dense food during your window, and listen to your body. As with any health practice, consistency matters more than perfection — find the schedule that fits your lifestyle and stick with it.总结一下:间歇性断食是体重管理和代谢健康方面最灵活、最有效的工具之一。从温和的方法(如 16:8)开始,保持水分,在进食窗口内吃营养密集的食物,并听从自己的身体。和任何健康实践一样,坚持比完美更重要——找到适合你生活方式的节奏并坚持下去。

👨‍⚕️ 作者:Author: 热量管理助手编辑团队 — 专注科学饮食与健康管理知识普及。本文内容基于公开学术文献和权威营养学指南整理。 Calorie Manager Editorial Team — Dedicated to evidence-based nutrition and health management education. Content compiled from peer-reviewed literature and authoritative dietary guidelines.

📚 参考文献:References: de Cabo R, Mattson MP. (2019). Effects of intermittent fasting on health, aging, and disease. N Engl J Med, 381(26):2541-2551. • Hartman ML, et al. (1992). Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast. J Clin Endocrinol Metab, 74(4):757-765. • Longo VD, Mattson MP. (2014). Fasting: molecular mechanisms and clinical applications. Cell Metab, 19(2):181-192. • Patterson RE, Sears DD. (2017). Metabolic effects of intermittent fasting. Annu Rev Nutr, 37:371-393. de Cabo R, Mattson MP. (2019). Effects of intermittent fasting on health, aging, and disease. N Engl J Med, 381(26):2541-2551. • Hartman ML, et al. (1992). Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast. J Clin Endocrinol Metab, 74(4):757-765. • Longo VD, Mattson MP. (2014). Fasting: molecular mechanisms and clinical applications. Cell Metab, 19(2):181-192. • Patterson RE, Sears DD. (2017). Metabolic effects of intermittent fasting. Annu Rev Nutr, 37:371-393.

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